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Theatrical release: October 26, 2001
Muze/MTS Inc.
| Kevin Spacey | Prot |
| Jeff Bridges | Dr. Mark Powell |
| Mary McCormack | Rachel Powell |
| Alfre Woodard | Dr. Claudia Villars |
| David Patrick Kelly | Howie |
| Saul Williams | Ernie |
| Peter Gerety | Sal |
| Celia Weston | Doris Archer |
| Ajay Naidu | Dr. Chakraborty |
| Tracy Vilar | Maria |
| Melanee Murray | Bess |
| John Toles-Bey | Russell |
| Kimberly Scott | Joyce Trexler |
| Conchata Ferrell | Betty McAllister |
| Vincent Laresca | Navarro |
| Mark Christopher Lawrence | Simms |
| Brian Howe | Steve |
| Mary Mara | Abby |
| Tess McCarthy | Natalie Powell (Age 6) |
| Natasha Dorfhuber | Gabby Powell (Age 9) |
| Brandon Michael de Paul | Josh (Age 10) |
| Aaron Paul | Michael Powell (Age 21) |
| William Lucking | Sheriff |
| Kelly Connell | Walter Fleen |
| Peter Maloney | Duncan Flynn |
| Lance E. Nichols | David Patel |
| Paul Linke | Stuart Hessler |
| Christopher Jason Brown | Danny Trexler |
| Greg Lewis | Dominic McAllister |
| Clarke Peters | Homeless Veteran |
| Olga Merediz | Transit Officer |
| Joe Holt | Transit Officer |
| Lola Pashalinski | Russian Woman |
| Kateri Walker | Sara Porter |
| Katya Abelski | Rebecca Porter |
| Scott Lincoln | Walker |
| Clebert Ford | Homeless Man |
| Norman Alden | Babbling Man |
| Rawle D. Lewis | Security Guard |
| Erik LaRay Harvey | Security Guard |
| Zofia Borucka | Woman on Train |
| Tony Rhune | Thug |
| Vincent Capone | Thug |
| Richard Burden | stunt player |
| Tim Gilbert | stunt player |
| Jennifer Lamb | stunt player |
| Phil Culotta | stunt player |
| Harry O'Connor | stunt player |
| Jim Palmer | stunt player |
| Tim Rigby | stunt player |
| Loyd Catlett | Stunt Double/Stand in for Mr. Bridges |
| B'Jahn | Ward Patient |
| Anne Carroll | Ward Patient |
| Lisa Cohen | Ward Patient |
| Clete Francis | Ward Patient |
| Leo Frank | Ward Patient |
| Valerie Giocondo | Ward Patient |
| William Godbolt | Ward Patient |
| Ralph Hadida | Ward Patient |
| Patrick Jankiewicz | Ward Patient |
| Josef Klus | Ward Patient |
| Coco Leigh | Ward Patient |
| Lydia Murray | Ward Patient |
| Rafael Real | Ward Patient |
| Julie Sands | Ward Patient |
| Frank Collison | Screaming Man |
| Moet Meira | Jennifer |
| Gene Smith | Ward Patient |
| Susan G. Pollock | Executive Producer |
| John Mathieson | Director of Photography |
| Craig McKay | Film Editor |
| Edward Shearmur | Composer |
| Sheryl Crow | Song Writer |
| Mark Weingarten | production sound mixer |
| Chris Jenkins | Sound Re-Recording Mixer |
| Frank Montano | Sound Re-Recording Mixer |
| Rick Kline | Sound Re-Recording Mixer |
| J. Paul Huntsman | Supervising Sound Editor |
| Tim Webb | sound |
| Stephen Neary | sound |
| John Beard | Production Designer |
| Alexander Hammond | Art Director |

