In ganz Europa tobt der Zweite Weltkrieg und richtet unendliche Verwüstung an. Der junge Steven Rogers (Chris Evans) ist fest entschlossen, sein Land im Kampf um Frieden und Freiheit zu unterstützen, doch seine Körperkraft reicht für den gefährlichen Kriegseinsatz nicht aus. Unbeirrt stellt er sich nach seiner Ausmusterung für eine mysteriöse Versuchsreihe zur Verfügung: Das Super-Soldier-Programm macht aus dem unscheinbaren Mann eine unschlagbare menschliche Waffe Captain America ist geboren! Kaum ist der neue Kriegsheld auf dem umkämpften Kontinent angekommen, steht ihm die bisher größte Prüfung seines Lebens bevor: Der Kampf gegen Nazi-Agent Red Skull (Hugo Weaving), der als absolut unbesiegbar gilt. Um ihn zu stoppen, muss Captain America sich selbst opfern
| Chris Evans | Captain America |
| Samuel L. Jackson | Nick Fury |
| Hayley Atwell | Peggy Carter |
| Hugo Weaving | Johann Schmidt |
| Sebastian Stan | James Buchanan 'Bucky' Barnes |
| Toby Jones | Dr. Arnim Zola |
| Tommy Lee Jones | Colonel Chester Phillips |
| Dominic Cooper | Howard Stark |
| Neal McDonough | Timothy 'Dum Dum' Dugan |
| Stanley Tucci | Dr. Abraham Erskine |
| Natalie Dormer | Pvt. Lorraine |
| Richard Armitage | Heinz Kruger |
| JJ Feild | James Montgomery Falsworth |
| Derek Luke | Gabe Jones |
| Bruno Ricci | Jacques Dernier |
| Kenneth Choi | Jim Morita |
| Lex Shrapnel | Gilmore Hodge |
| Michael Brandon | Senator Brandt |
| Anatole Taubman | Roeder |
| Eric Edelstein | |
| Martin Sherman | Brandt's Aide (as Martin T. Sherman) |
| Christian Black | |
| Oscar Pearce | Search Team Leader |
| Marek Oravec | Jan |
| William Hope | SHIELD Lieutenant |
| Chris Jorie | Reporter (as Chris Jorie) |
| Nicholas Pinnock | SHIELD Tech |
| David Bradley | Tower Keeper |
| Leander Deeny | Barman |
| Sam Hoare | Nervous Recruit |
| Simon Kunz | 4F Doctor |
| Kieran O'Connor | Loud Jerk |
| Jenna-Louise Coleman | Connie |
| Sophie Colquhoun | Bonnie |
| Doug Cockle | Young Doctor |
| Ben Batt | Enlistment Office MP |
| Mollie Fitzgerald | Stark Girl |
| Damon Driver | Sergeant Duffy |
| David McKail | Johann Schmidt's Artist |
| Amanda Walker | Antique Store Owner |
| Richard Freeman | SSR Doctor |
| Katherine Press | Project Rebirth Nurse |
| Sergio Corvino | Kruger's Aide |
| Marcello Walton | Undercover Bum |
| Vincent Montuel | Undercover Bum |
| Fabrizio Santino | Kruger's Driver |
| Maxwell Newman | Boy at Dock |
| Jan Pohl | Hutter |
| Erich Redman | Schneider |
| Rosanna Hoult | The Star Spangled Singer |
| Naomi Slights | The Star Spangled Singer |
| Kirsty Mather | The Star Spangled Singer |
| Megan Sanderson | Kid in USO Audience |
| Darren Simpson | Kid in USO Audience |
| Fernanda Toker | Newsstand Mom |
| Laura Haddock | Autograph Seeker |
| James Payton | 'Adolph Hitler' |
| Ronan Raftery | Army Heckler |
| Nick Hendrix | Army Heckler |
| Luke Allen-Gale | Army Heckler |
| Jack Gordon | Army Heckler |
| Ben Uttley | HYDRA Guard |
| Kevin Millington | Stark's Engineer |
| Patrick Monckeberg | Manager Velt |
| Peter Stark | HYDRA Lieutenant |
| Amanda Righetti | SHIELD Agent |
| Jennifer Abbotts | USO Dancer |
| Michelle Antrobus | USO Dancer |
| Lucy Dean | USO Dancer |
| Erin Dusek | USO Dancer |
| Nicole Evans | USO Dancer |
| Lizzi Franklin | USO Dancer |
| Emma Harris | USO Dancer |
| Rachael Isherwood | USO Dancer |
| Danielle Kelly | USO Dancer |
| Nicole May | USO Dancer |
| Stevie-Jean McGuire | USO Dancer |
| Anna McNicholas | USO Dancer |
| Rosie Pethullis | USO Dancer |
| Jessica Powell | USO Dancer |
| Rachel Quartley | USO Dancer |
| Sarah Riches | USO Dancer |
| Holly Rostron | USO Dancer |
| Caroline Royce | USO Dancer |
| Stephanie Jayne Thompson | USO Dancer |
| Lucie Waugh | USO Dancer |
| Billy Lozowski | USO Drummer |
| Gregory Paulett | USO Drummer |
| Adam Birch | USO Drummer |
| Adam Kent | USO Drummer |
| Wiliam Morris | USO Drummer |
| David Sdall | USO Drummer |
| Paul Simmons | USO Drummer |
| Marc Wheeler | USO Drummer |
| Chris Diggle | USO Drummer |
| Michael Humphrey | USO Drummer |
| James Chahine | Army Heckler |
| Brian Niblett | Theatre Spectator |
| Martin Poole | Theatre Spectator |
| Francesca Neri |
