John Travolta (Phenomenon en Pulp Fiction) speelt de detective Sean Archer die, koste wat het kost, de psychotische terrorist Castor Troy (Nicolas Cage- The Rock en Con Air) wil pakken. Castor, verantwoordelijk voor de dood van Sean's zoon, wordt gearresteerd maar raakt in coma. Hij heeft Sean echter nog net verteld dat er in San Francisco een biologische bom verborgen ligt. Teneinde op het spoor van de bom te kunnen komen, wordt Sean door regeringsfunctionarissen gevraagd zich uit te geven als Castor. Door middel van een medische ingreep worden de gezichten van Sean en Castor verwisseld. Sean neemt Castor's leven over, maar intussen ontwaakt deze uit zijn coma, ontsnapt uit het ziekenhuis en neemt Sean's identiteit aan. Castor Troy maakt de bom onschadelijk en wordt een publieke held. De Èchte Sean moet Castor zien te pakken om zijn leven terug te krijgen.
| John Travolta | Sean Archer/Castor Troy |
| Nicolas Cage | Castor Troy/Sean Archer |
| Joan Allen | Dr. Eve Archer |
| Alessandro Nivola | Pollux Troy |
| Gina Gershon | Sasha Hassler |
| Dominique Swain | Jamie Archer |
| Nick Cassavetes | Dietrich Hassler |
| Harve Presnell | Victor Lazarro |
| Colm Feore | Dr. Malcolm Walsh |
| John Carroll Lynch | Walton |
| CCH Pounder | Dr. Holllis Miller |
| Robert Wisdom | Tito Biondi |
| Margaret Cho | Wanda |
| Jamie Denton | Buzz |
| James Denton | Buzz |
| Matt Ross | Loomis |
| Chris Bauer | Ivan Dubov |
| Myles Jeffrey | Michael Archer |
| David McCurley | Adam Hassler |
| Thomas Jane | Burke Hicks |
| Tommy Flanagan | Leo |
| Dana Smith | Lars |
| Romy Walthall | Kimberly |
| Romy Windsor | Kimberly |
| Paul Hipp | Fitch |
| Kirk Baltz | Aldo |
| Lauren Sinclair | Agent Winters |
| Ben Reed | Pilot |
| Lisa Boyle | Cindee |
| Linda Hoffman | Livia |
| Danny Masterson | Karl |
| Michael Rocha | Priest |
| Father Michael Rocha | Priest |
| Megan Paul | Hospital Girl |
| Mike Werb | Hospital Dad |
| Tom Reynolds | LAPD Cop |
| Steve Hytner | Interrogating Agent |
| Carmen Thomas | Valerie |
| John Bloom | Shock Technician |
| Walter Scott | Port Police Commander |
| Brooke Leslie | ER Nurse |
| Cam Brainard | Dispatcher |
| David Warshofsky | Bomb Leader |
| John Neidlinger | Bomb Technician |
| Norm Compton | Cigarette Guard |
| Gregg Shawzin | Lockdown Guard |
| Clifford Einstein | Restorative Surgeon |
| Marco Kyris | Recreation Guard |
| Tom Fridley | Prison Guard |
| Andrew Wallace | Altar boy |
| Jacinto Rodriguez | Prisoner |
| Chic Daniel | FBI Squad Leader |
| Laurence Walsh | Walsh Clinical Nurse |
| Thomas Rosales, Jr. | Prisoner |
| Billy Morts | Dietrich's man/Man who holds Adam (uncr) |
| Robert Zajonc | Helicopter Pilot |
| Thomas Rosales Jr. | Prisoner |
| Robert 'Bobby Z' Zajonc | Helicopter Pilot |
| Michael Douglas | Executive Producer |
| Jonathan D. Krane | Executive Producer |
| Steven Reuther | Executive Producer |
| Oliver Wood | Director of Photography |
| Steven Kemper | Film Editor |
| Christian Wagner | Film Editor |
| John Powell | Composer |
| David Ronne | production sound mixer |
| Susan Kurtz | Sound Editor |
| Anna Behlmer | Sound Re-Recording Mixer |
| Andy Nelson | Sound Re-Recording Mixer |
| Tom Perry | Sound Re-Recording Mixer |
| David M. Ronne | production sound mixer |
| Ellen Mirojnick | Costume Designer |
| Mark P. Stoeckinger | Supervising Sound Editor |
| Neil Spisak | Production Designer |
| Boyd Shermis | Visual Effects |
| Richard Hollander | Visual Effects |
| Steve Arnold | Art Director |
| Kevin Yagher | Make-up Effects |
| Richard Zarro | Visual Effects |
| David Atherton | Make-Up Artist |
| Michelle Buhler | Make-Up Artist |
| Allen Weisinger | Make-Up Artist |
| Gil Mosko | Make-Up Artist |
| Nina Kraft | Make-Up Artist |
| Michael Dennison | Costume Designer |
| H. Dwight Raymond IV | Visual Effects |
| Derek Spears | Visual Effects |
