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The movie opens with professor Sherman Klump barely holding onto his sanity as his internal Buddy Love makes him say inappropriate things. He decides to extract his mutant Buddy Love gene (a sort of genetic version of electroshock therapy), but afterward is unable to maintain his original personality and intelligence. Sherman is the most bland character of the bunch, and the audience gets stuck with his boring romance with fellow professor Janet Jackson, his struggle to be nice, and generic intrigue surrounding a Fountain of Youth formula he developed. When it's not trying too hard to be nice--heck, one character is anally raped by a giant hamster--the movie works. The moral of the story is that Sherman needs to reconnect with his inner Buddy Love. That goes for Murphy, too.
From the Back Cover
Eddie Murphy is hilarious when he stars as the entire Klump family in this enormous comedy blockbuster
The hilarity begins when professor Sherman Klump finds romance with fellow DNA specialist, Denise Gaines ( Janet Jackson), and discover a brilliant formula that reverses aging. But Sherman's thin and obnoxious alter ego, Buddy Love, wants out and a big piece of the action. And when Buddy gets loose, things get seriously nutty. Now, it's up to Mama, Papa, Ernie and Granny Klump to throw their weight around and save the day.
| Eddie Murphy | Professor Sherman Klump |
| Janet Jackson | Professor Denise Gaines |
| Larry Miller | Dean Richmond |
| John Ales | Jason |
| Richard Gant | Mr. Gaines |
| Anna Maria Horsford | Mrs. Gaines |
| Melinda McGraw | Leanne Guilford |
| Jamal Mixon | Ernie Klump, Jr. |
| Gabriel Williams | Isaac |
| Chris Elliott | Restaurant Manager |
| Duffy Taylor | Restaurant Trainee |
| Earl Boen | Dr. Knoll |
| Nikki Cox | Ms. Stamos |
| Freda Payne | Claudine |
| Sylvester Jenkins | Old Willie |
| Wanda Sykes | Chantal |
| George King | Stripper |
| Charles Walker | Preacher |
| Enya Flack | Bridesmaid |
| Kym E. Whitley | Party Guest |
| Andrea C. Robinson | Party Guest/Bridesmaid |
| Selma Stern | Mrs. Dudikoff |
| Julia Schultz | Receptionist |
| Barry W. Blaustein | Man in Bathroom |
| David Sheffield | Man in Bathroom |
| Kathleen Freeman | Nosy Neighbor |
| Ralph Drischell | Zeke |
| Myles Mason | Baby Buddy |
| Jeffrey Michael Freeman | Baby Buddy |
| Maurice Colquitt | Baby Buddy |
| Bill Applebaum | Boardroom Member |
| Harry S. Murphy | Boardroom Member |
| Tom Jourden | Guy in Elevator |
| Shawnette Heard | Dancer |
| Andrea Kelly Konno | Dancer |
| Laurie Sposit | Dancer |
| Nadine Ellis | Dancer |
| Kevin Michael Mondane | Buddy at 15 |
| Viola Kates Stimpson | Sweet Old Lady |
| Naomi Kale | Buxom Student |
| Kente Scott | Fraternity Student |
| Justin Urich | Lecture Student |
| Sonya Eddy | Heavyset Woman |
| James D. Brubaker | Krusty Reporter |
| Richie Palmer | Cab Driver |
| Charles Napier | Four Star General |
| Steve Kehela | Scientist |
| Miguel A. Núñez Jr. | Scientist |
| Renee Tenison | Dog Owner |
| Richard Saxton | American Newscaster |
| Peter Segal | Scared Popcorn Man |
| William Kerr | Scared Popcorn Man |
| Michael Ewing | Hot Dog Vendor |
| Nicole Segal | Scared Little Girl |
| Diva | Snooty Woman |

