Married doctors William and Dakota Block (Josh Brolin and Marley Shelton) find their graveyard shift inundated with townspeople ravaged by gangrenous sores and a suspiciously vacant look in their eyes. Among the wounded is Cherry Darling (Rose McGowan), a go-go dancer whose leg was ripped off during a roadside attack, and El Wray (Freddy Rodriguez), a mysterious drifter with a past. Cherry may be down on her luck, but she hasn't danced her last number...

As the virus turns the invalids into enraged aggressors, Cherry and El Wray lead a team of accidental warriors into the night, hurtling towards a destiny that will leave millions infected, countless dead and a lucky few heading for the last safe corner of PLANET TERROR.