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Pekar, played by Paul Giamatti, is a frustrated file clerk at a V.A. Hospital, but also a comic book fan who befriends the young illustrator Robert Crumb and is soon inspired to create comic books based on his own life, entitled AMERICAN SPLENDOR. Along the bumpy journey, he meets, marries and falls for Joyce, an admiring comic book seller, played by Hope Davis.
Also appearing in the movie are the real Harvey and Joyce, comic book renderings of the couple and cameos by some of Harvey's closest friends. In this truly original, ultimately heartwarming film, you will find yourself deeply immersed in a world of AMERICAN SPLENDOR.
| Chris Ambrose | Superman |
| Joey Krajcar | Batman |
| Josh Hutcherson | Robin |
| Cameron Carter | Green Lantern |
| Daniel Tay | Young Harvey |
| Mary Faktor | Housewife |
| Paul Giamatti | Harvey Pekar |
| Harvey Pekar | Real Harvey |
| Shari Springer Berman | Interviewer |
| Larry John Meyers | Throat Doctor |
| Hope Davis | Joyce Brabner |
| Vivienne Benesch | Lana |
| Barbara Brown | Nurse |
| Earl Billings | Mr. Boats |
| Danny Hoch | Marty |
| James Urbaniak | Robert Crumb |
| Eli Ganias | Pahls |
| Sylvia Kauders | Old Jewish Lady |
| Rebecca Borger | Cashier |
| Nick Baxter | Mattress Guy #1 |
| Allen Branstein | Mattress Guy #2 |
| Dick Prochaska | WW II Patient |
| Charles Eduardos | Doctor |
| Judah Friedlander | Toby Radloff |
| Robert Pulcini | Bob The Director |
| Toby Radloff | Real Toby |
| Bianca Santos | Counter Girl |
| Maggie Moore | Alice Quinn |
| Mike Rad | Rand |
| Amy K. Harmon | Cheery Waitress |
| Joyce Brabner | Real Joyce |
| Donal Logue | Stage Actor Harvey |
| Molly Shannon | Stage Actor Joyce |
| Eytan Mirsky | Guitarist |
| Rob Grader | Stage Manager |
| Terrence Sullivan | Letterman Regular |
| Ebon Moss-Bachrach | MTV Director |
| Patrick Lafferty | Yuppie |
| Jesse Perez | Miguel |
| Jeff Peters | Talk Show Host |
| Ola Creston | PA #1 |
| Robert J. Williams | Cancer Doctor |
| James McCaffrey | Fred |
| Madylin Sweeten | Danielle |
| Danielle Batone | Real Danielle |
| Jason Stevens | Letterman Regular Voice |
| Todd Cummings | Talk Show Host Voice |
| Cody Cover | Boy at Candy Machine |
| David Letterman | Himself (archive footage) |
| Terry Stacey | Director of Photography |
| Mark Suozzo | Composer |
| Whit Norris | production sound mixer |
| Ron Bochar | Sound Re-Recording Mixer |
| Nicholas Renbeck | Supervising Sound Editor |
| Michael Wilkinson | Costume Designer |
| Thérèse DePrez | Production Designer |
| Murshel C. Lewis | Costume Designer |
| Luisa Abel | Make-Up Artist |

