With stolen top-secret technology, terrorists have created a next-generation Universal Soldier - an elite fighter genetically altered into a programmable killing machine. With this "UniSol" (Former UFC Heavyweight Champion Andrei "The Pitbull" Arlovski) leading the way, they seize the crippled Chernobyl nuclear reactor, threatening to unleash a lethal radioactive cloud.
The only one who can stop them is Luc Deveraux (Jean-Claude Van Damme), a UniSol who's been decommissioned for years. Reactivated and retrained, Deveraux must make a full-out assault on the heavily armed fortress. But inside, he'll discover not one, but two of these virtually indestructible warriors. Andrew Scott (Dolph Lundgren), Deveraux's vicious UniSol enemy from the original Universal Soldier, has been secretly reanimated and upgraded.
Now these elite fighters are locked, loaded and programmed to kill, and the fate of millions hinges on this high-action showdown.
| Jean-Claude Van Damme | Luc Deveraux |
| Dolph Lundgren | Andrew Scott |
| Andrei Arlovski | NGU |
| Mike Pyle | Captain Kevin Burke |
| Garry Cooper | Dr. Porter |
| Emily Joyce | Dr. Sandra Flemming |
| Zahary Baharov | Commander Topov |
| Aki Avni | General Boris |
| Kerry Shale | Dr. Colin |
| Yonko Dimitrov | Dimitri |
| Violeta Markovska | Ivana |
| Stanislav Pishtalov | P. M. Musayev |
| Marianne Stranicheva | Olga |
| John Laskowski | Captain |
| Kristopher Van Varenberg | Miles |
| Franklin A. Vallette | Technician |
| Shelly Varod | Translator |
| Radina Kardjilova | Waitress |
| Trayan Milenov | Unisol 1 |
| Jon Foo | Unisol 2 |
| Danko Jordanov | Unisol 3 |
| Dian Hristov | Unisol 4 |
| Mark Damon | Executive Producer |
| Courtney Solomon | Executive Producer |
| Peter Hyams | Cinematographer |
| Jason Gallagher | Film Editor |
| John Hyams | Film Editor |
| Kris Hill | Composer |
| Michael Krassner | Composer |
| Jeff Seelye | Sound Editor |
| Philip Harrison | Production Designer |
| Rossita Bakeva | Art Director |
| Sonia Despotova | Costume Designer |
