This season, Chuck is in luck. Intersect II is ready for espionage service. And that means the old Intersect (Chuck) can go back to his old life. But if Chuck goes, he's gone: Casey has orders to off him. In the series called "TV's funniest comedy" by EW.com, Chuck survives to unravel mysteries of the past, become a hero in the present, and in a stunner of a season finale chop-and-drop himself into an even more perilous future!
Episodes:
1. Chuck Versus the First Date
2. Chuck Versus the Seduction
3. Chuck Versus the Break-Up
4. Chuck Versus the Cougars
5. Chuck Versus Tom Sawyer
6. Chuck Versus the Ex
7. Chuck Versus the Fat Lady
8. Chuck Versus the Gravitron
9. Chuck Versus the Sensei
10. Chuck Versus the Delorean
11. Chuck Versus the Santa Claus
12. Chuck Versus the Theird Dimension
13. Chuck Versus the Suburbs
14. Chuck Versus the Best Friend
15. Chuck Versus the Beefcake
16. Chuck Versus the Lethal Weapon
17. Chuck Versus the Predator
18. Chuck Versus the Broken Heart
19. Chuck Versus the Dream Job
20. Chuck Versus the First Kill
21. Chuck Versus the Colonel
22. Chuck Versus the Ring
| Zachary Levi | Charles |
| Yvonne Strahovski | Sarah Walker |
| Joshua Gomez | Morgan Grimes |
| Ryan McPartlin | Dr. Devon 'Captain Awesome' Woodcomb |
| Mark Christopher Lawrence | Michael |
| Scott Krinsky | Jeffrey Barnes |
| Vik Sahay | Lester Patel |
| Julia Ling | Anna Wu |
| Sarah Lancaster | Dr. Eleanor |
| Adam Baldwin | John Casey |
| Michael Clarke Duncan | Colt |
| Bonita Friedericy | General Diane Beckman |
| Tony Todd | CIA Director Graham |
| Mark Brandon | World Send Driver |
| Matt Sigloch | Tactical Trooper |
| John Larroquette | Roan Montgomery |
| Matthew Bomer | Bryce Larkin |
| Melinda Clarke | Sasha Banacheck |
| Matthew Jay Cwern | Handsome Cool Guy |
| Adam Sauter | Employee |
| Manny Hernandez | Messenger |
| Sarah Pointer | Stewardess |
| Treisa Gary | Woman |
| Nathan Sutton | Agent Epstein |
| Michael Strahan | Mitt |
| Steve Valentine | Von Hayes |
| Bianca Chiminello | Agent |
| Sven Garrett | Hans |
| Marcy Goldman | Nurse |
| Gino Anthony Pesi | Bad Guy #1 |
| Stephen Holland | Barry Nyes |
| Tim Chiou | Mighty Jock |
| Royce Thomas Johnson | Waiter |
| Roberto Sanchez | Columbian |
| Nicole Richie | Heather Chandler |
| Ben Savage | Mark Ratner |
| Michael Weaver | Dick Duffy |
| Adam Bergerson | Drunk Guy |
| Jennifer Bronstein | Enthusiastic Girl |
| Sonora Chase | Woman |
| Kai Schmoll | Male Customer |
| Brandon Ford Green | Conscientious Customer |
| Hope Shapiro | Bunny |
| Tony Hale | Emmett Milbarge |
| Clyde Kusatsu | Morimoto |
| Faran Tahir | Farrokh Bulsara |
| Bill Lewis | Stu Brewster |
| Rob Chester Smith | Engineer #1 |
| Martin Yu | Engineer #2 |
| Mitchell Fink | Airman |
| Amy Shelton-White | Local News Anchor |
| Jared Wilder | Jeering Nerd |
| William Abadie | Guy Lafleur |
| Jordana Brewster | Dr. Jill Roberts |
| Zack Hanks | Rommell |
| Elaine Loh | Shari |
| Ammar Ramzi | Lonnie |
| Tom Sean Foley | FBI Guy |
| Jason E. Kelley | Piano Player |
| Zokai Holmes | Valet |
| Sinqua Walls | Student |
| Mark Pellegrino | Fulcrum agent |
| Phillipe Simon | Opera Director |
| Brandon Brendel | Bellboy #1 |
| Jim Pacitti | FBI Agent #1 |
| Patrick Kilpatrick | Leader |
| Morgan Fairchild | Honey Woodcomb |
| Bruce Boxleitner | Dr. Woody Woodcomb |
| Carl Lumbly | Ty Bennett |
| Michael Kawczynski | Skip |
| John Knox | SWAT Leader |
| Dwayne Standridge | Town Car Driver |
| Gary Cole | Jack Burton |
| Anthony Azizi | Sheik Rajiv Amad |
| Craig Susser | DeLorean Owner |
| Dominic Comperatore | Translator |
| David Trice | Manager |
| Debbie Cambell | Porter |
| Gil Glasgow | Guard #1 |
| Alexander Fazel | Thug #1 |
| Stefanie Scott | Sarah at 12 Years Old |
| Jed Rees | Nathan Edward 'Ned' Rhyerson |
| Reginald VelJohnson | Sgt. Al Powell |
| Michael Rooker | Mauser |
| Tina Huang | Maureen Mitsubishi |
| Matt Riedy | Swat Captain |
| Lony'e Perrine | Buy More Employee |
| Dominic Monaghan | Tyler Martin |
| Jerome Bettis | Jimmy Butterman |
| Harry Van Gorkum | |
| Nicholas Guilak | Achmed Gambir |
| Luisa Moraes | Vixen #1 |
| Nina Fehren | Vixen #2 |
| Andy Richter | Brad White |
| Patricia Rae | Bolonia Grimes |
| Jenny Mcarthy | Sylvia Arculin |
| Brian Thompson | Cliff |
| Alison Paul | Vanessa |
| Darren Keefe | Yeager |
| Jennifer Jalene | Smooth Lau |
