Most men would do anything to get out of Fox River Penitentiary, but Michael Scofield (Wentworth Miller) will do anything to get in. His brother Lincoln (Dominic Purcell) has been sentenced to die for a crime he did not commit, and the only way to save him is from the inside out.
Armed with prison blueprints and an impossibly intricate escape plan, Michael gets himself incarcerated, and the race against time is on. Now, he'll need all of the cunning, daring, and luck he can muster...along with the assistance of some of the prison's most vile and dangerous felons.
EPISODES:
1. Pilot
2. Allen
3. Cell Test
4. Cute Poison
5. English, Fitz or Percy
6. Riots, Drills and the Devil (Part 1)
7. Riots, Drills and the Devil (Part 2)
8. The Old Head
9. Tweener
10. Sleight of Hand
11. And Then There Were Seven
12. Odd Man Out
13. End of the Tunnel
14. The Rat
15. By The Skin & The Teeth
16. Brother's Keeper
17. J-Cat
18. Bluff
19. The Key
20. Tonight
21. Go
22. Flight
| Dominic Purcell | Lincoln Burrows |
| Wentworth Miller | Michael Scofield |
| Robin Tunney | Veronica Donovan |
| Amaury Nolasco | Fernando Sucre |
| Marshall Allman | LJ Burrows Jr. |
| Peter Stormare | John Abruzzi |
| Wade Williams | Captain Brad Bellick |
| Sarah Wayne Callies | Dr. Sara Tancredi |
| Rockmond Dunbar | Benjamin Miles 'C-Note' Franklin |
| Jessalyn Gilsig | Lisa Rix |
| Muse Watson | Charles Westmoreland |
| Paul Adelstein | Agent Paul Kellerman |
| Camille Guaty | Maricruz |
| Chelcie Ross | Bishop McMorrow |
| Laura Scott Wade | Sid |
| Stacy Keach | Warden Henry Pope |
| Danny McCarthy | Hale |
| Rolando Boyce | Cop |
| Cheryl Lynn Bruce | Judge |
| Nicolas Iovino | Brian |
| Ora Jones | Wendy |
| Rich Komenich | Maggio |
| Christian Stolte | C.O. #1 |
| Phillip Edward Van Lear | C.O. #2 |
| Jay Whitaker | Sweatsuit |
| Peggy Roeder | Teller |
| Gianni Russo | Smallhouse |
| Phil Rayburn Smith | Adrian Rix |
| Anthony Starke | Sebastian |
| Jeff Parker | Tsili |
| Alan Wilder | Prison Chaplain |
| Dan Maxwell | Cronie #1 |
| David Pacheco | Speaking Prisoner #1 |
| Darnell Jackson | Speaking Prisoner #2 |
| Billy Chase | Speaking Prisoner #3 |
| Robert Knepper | Theodore 'T-Bag' Bagwell |
| Al Sapienza | Falzone |
| Kurt Caceres | Hector |
| Keith Diamond | Tim Giles |
| Adina Porter | Leticia Barris |
| Wesley Walker | Aryan Brother |
| Anthony Fleming | Black Inmate #2 |
| Mark Morettini | C.O. #4 |
| Chavez Ravine | Ms. Simmons |
| Brian Hamman | Maytag |
| DuShon Brown | Infirmary Nurse |
| David Lively | Terrence Steadman |
| John Conrad | Garlic Cutter's Grandkid |
| Ashley Boetcher | Garlic Cutter's Grandkid |
| Silas Weir Mitchell | Haywire |
| Peter Reinemann | Gus |
| Sandra Marquez | Mrs. Delgado |
| Linara Washington | Jenae Conlin |
| Tom McElroy | Reverend Mailor |
| Mac Brandt | C.O. #1 |
| Tab Baker | Crab Simmons |
| Jason Wells | White Cap |
| Lillian Almaguer | Abruzzi Kid #1 |
| Elijah Roberts | Abruzzi Kid #2 |
| Tracey Bonner | Old African American Lady |
| Frank Grillo | Nick Savrinn |
| Deanna Dunagan | Judy |
| Cedric Young | Choppy |
| John Judd | Ben Forsik |
| Jennifer Joan Taylor | Becky |
| Theron Touché Lykes | Random Inmate |
| Mike Vieau | ZZ |
| Kevin Kelly | Officer Weston |
| Jennifer Kern | Allison |
| Dylan Minnette | Young Michael |
| Max Kirsch | Young Lincoln |
| Joe Minoso | Chaz Fink |
| Jane Galloway Heitz | Uppity Clerk |
| John Heard | Governor Frank Tancredi |
| Michael Cudlitz | C.O. Bob |
| Matt DeCaro | C.O. Geary |
| Daniel J. Travanti | President Richard Mills |
| Paul Noble | Eric Diamond |
| Howie Johnson | Lukasz |
| John Turk | Green String Inmate / Turk |
| Robert Michael Vieau | Trokey |
| Blaine Hogan | Seth / Cherry |
| Brad Fleischer | Pop Pop / Theo |
| Kwame Amoaku | Stroker |
| David McCoy | Adam Diamond |
| Daniel Allen Ruben | Sick Bay Con #1 |
| Ana Berry | Flight attendant |
| Braden Moran | Captain |
| Michael Stoyanov | Fletch |
| James Alfred | Sniper |
| Bob Sirott | Field Reporter |
| Morocco Omari | Ron |
| Patricia Wettig | The Vice President |
| Jacqueline Williams | Sue Parsons |
| Rebecca Spence | Shauna Hudson |
| Philip Rayburn Smith | Adrian |
| Gary Brichetto | Fire Inspector |
| James Meredith | Secret service agent |
| Lane Garrison | David 'Tweener' Apolskis |
| Michael T. Weber | Knowlton |
