Robert Downey JR. speelt de sterren van de hemel als Dolittle, de man die met de dieren kan praten. Na de dood van zijn geliefde vrouw trekt Dolittle zich ontroostbaar terug op zijn landgoed. Maar wanneer de koningin erg ziek wordt, moet de kluizenaar noodgedwongen het avontuur aangaan. Tijdens zijn epische zoektocht naar een zeldzame remedie krijgt hij een helpende poot van zijn onstuimige dierenvrienden: Chee-Chee (Oscar®winnaar Rami Malek), een angstige, onzekere gorilla; Dab-Dab (Oscar®winnares* Octavia Spencer), een enthousiaste eend die ze af en toe ziet vliegen; de cynische, neurotische struisvogel Plimpton (Kumail Nanjiani), die voortdurend overhoop ligt met de coole, maar ijzige ijsbeer Yoshi (John Cena) en de eigenwijze papegaai Polynesia (Oscar®winnares Emma Thompson).
2018, Actor in a Leading Role, Bohemian Rhapsody. *2011, Actress in a Supporting Role, The Help. 1992, Actress in a Leading Role, Howards End; 1995, Screenplay Based on Material Previously Produced or Publiced, Sense and Sensibility.
| Robert Downey, Jr. | Dr. John Dolittle |
| Antonio Banderas | King Rassouli |
| Michael Sheen | Dr. Blair Müdfly |
| Jim Broadbent | Lord Thomas Badgley |
| Jessie Buckley | Queen Victoria |
| Harry Collett | Tommy Stubbins |
| Emma Thompson | Poly |
| Rami Malek | Chee-Chee |
| John Cena | Yoshi |
| Kumail Nanjiani | Plimpton |
| Octavia Spencer | Dab-Dab |
| Tom Holland | Jip |
| Craig Robinson | Kevin |
| Ralph Fiennes | Barry |
| Selena Gomez | Betsy |
| Marion Cotillard | Tutu |
| Kasia Smutniak | Lily Dolittle |
| Carmel Laniado | Lady Rose |
| Frances de la Tour | Dragon |
| Jason Mantzoukas | James the Dragonfly |
| Ralph Ineson | Arnall Stubbins |
| Joanna Page | Bethan Stubbins |
| Sonny Serkis | Arnall Stubbins Jr |
| Oliver Chris | Sir Gareth |
| Clive Francis | Archbishop |
| Paul Holowaty | Navy Man |
| Elliot Barnes-Worrell | Captain William Derrick |
| Mark Umbers | Lieutenant |
| David Sheinkopf | Don Carpenterino |
| Sid Sagar | Jeff the Prisoner |
| Martin Pemberton | Postman |
| Tim Treloar | Humphrey the Whale |
| Nick Fisher | Mini the Sugar Glider |
| Jim Carretta | Beard Mouse and Leona |
| Matt King | Clyde |
| Ranjani Brow | |
| Kelly Stables | |
| Scott Menville | |
| Matthew Wolf | Army Ant |
| Gia Davis | |
| Henry Holcomb | |
| Kyrie McAlpin | |
| Isley Zamora | |
| Stewart Scudamore | |
| Samson Kayo | |
| John-Luke Roberts | |
| Joseph Balderrama | |
| Daniel Hoffmann-Gill | |
| Jane Leaney | |
| Josh Jefferies | |
| Shaun McKee | |
| Richard Soames | |
| Sarah Bradshaw | Executive Producer |
| Zack Roth | Executive Producer |
| Jonathan Liebesman | Executive Producer |
| Guillermo Navarro | Director of Photography |
| Craig Alpert | Film Editor |
| Chris Lebenzon | Film Editor |
| Danny Elfman | Composer |
| Sia Furler | Song Writer |
| Jesse Shatkin | Song Writer |
| Sean Douglas | Song Writer |
| Chris Munro | production sound mixer |
| Jon Taylor | Sound Re-Recording Mixer |
| Frank A. Montaño | Sound Re-Recording Mixer |
| Daniel Laurie | Supervising Sound Editor |
| J. R. Grubbs | Supervising Sound Editor |
| Al Nelson | Sound Designer |
| Dominic Watkins | Production Designer |
| Jenny Beavan | Costume Designer |
| Nicolas Aithadi | Visual Effects |
| John Dykstra | Visual Effects |
| Matt Gray | Art Director |
| Gary Tomkins | Art Director |
| Paul Laugier | Art Director |
| Thomas Whitehead | Art Director |
| Tom Weaving | Art Director |
| Will Coubrough | Art Director |
| Peter Dorme | Art Director |
| Alex Smith | Art Director |
| Marco Scotti | Costume Designer |
| Tim Aslam | Costume Designer |
| Daniel Phillips | Make-Up Artist |
| Pippa Woods | Make-Up Artist |
| Paula Price | Make-Up Artist |
| Loulia Sheppard | Make-Up Artist |
| Andrea Cracknell | Make-Up Artist |
| Dominic Tuohy | Visual Effects |
| Sébastien Raets | Visual Effects |
| Rob Allman | Visual Effects |
| Guy Pérez | Visual Effects |
| Alexis Liddell | Visual Effects |
| Jordi Lafebre | Visual Effects |
| David Alcarria Jiménez | Visual Effects |
| Jeremiah Sweeney | Visual Effects |
| Vincent Cirelli | Visual Effects |
| Kevin Souls | Visual Effects |
| Brendan Seals | Visual Effects |
