The series is set 97 years after a devastating nuclear war wiped out almost all life on Earth. The only known survivors are the residents of twelve space stations in Earth's orbit prior to the war. The space stations banded together to form a single massive station named "The Ark", where about 2,400 people live. Resources are scarce and all crimes no matter their nature or severity are punishable by death ("floating") unless the perpetrator is under 18 years of age. After the Ark's life support systems are found to be critically failing, one hundred juvenile prisoners are declared "expendable" and sent to the surface in a last ditch attempt to determine if Earth is habitable again. The teens arrive on a beautiful planet they've only seen from space. Confronting the dangers of this rugged new world, they struggle to form a tentative community. However they discover that not all humanity was wiped out. There are people on Earth who survived the war, called "grounders" by the 100. The ...
| Eliza Taylor | Clarke Griffin (30 episodes, 2014-2015) |
| Bob Morley | Bellamy Blake (30 episodes, 2014-2015) |
| Paige Turco | Dr. Abigail Griffin (30 episodes, 2014-2015) |
| Marie Avgeropoulos | Octavia Blake (30 episodes, 2014-2015) |
| Devon Bostick | Jasper Jordan (30 episodes, 2014-2015) |
| Christopher Larkin | Monty Green (30 episodes, 2014-2015) |
| Isaiah Washington | Chancellor Thelonious Jaha (30 episodes, 2014-2015) |
| Henry Ian Cusick | Councillor Marcus Kane (30 episodes, 2014-2015) |
| Lindsey Morgan | Raven Reyes (28 episodes, 2014-2015) |
| Ricky Whittle | Lincoln (25 episodes, 2014-2015) |
| Thomas McDonell | Finn Collins (22 episodes, 2014-2015) |
| Richard Harmon | John Murphy (20 episodes, 2014-2015) |
| Sachin Sahel | Jackson (15 episodes, 2014-2015) |
| Jarod Joseph | Nathan Miller (14 episodes, 2014-2015) |
