Stef Foster and Lena Adams, a lesbian couple, have a family of adopted, biological, and foster children. Mariana and Jesus are adopted 15 year old twins and Brandon is Stef's 16 year old biological son from a previous marriage. Everything is going normal in the house. Until Callie and Jude arrive. 16 year old Callie Jacob and her 12 year old brother, Jude, have been to many different foster homes. But when they get placed with the Fosters, things begin to happen. In this series, the Foster's will deal with many different issues including, hook ups, break ups, romances, and important life lessons.