John Carter (TAYLOR KITSCH) glaubt, alles schon erlebt, alles schon gesehen zu haben. Doch dann gerät der ehemalige Offizier, der nicht mehr kämpfen will, in einen Konflikt, der alle Vorstellungskraft sprengt. Auf unerklärliche Weise findet er sich auf einem geheimnisvollen Planeten wieder, den die Bewohner Barsoom nennen. Exotische Geschöpfe bevölkern diese Welt, aber auch fremdartige Stämme und Kulturen, die sich bekriegen und damit ihren eigenen Untergang heraufbeschwören. Auf seiner abenteuerlichen Odyssee durch eine fremde Welt, die am Abgrund steht, begegnet John Carter dem charismatischen Anführer Tars Tarkas (WILLEM DAFOE) und verliebt sich in die bezaubernde, selbstbewusste Prinzessin Dejah Thoris (LYNN COLLINS). Von unbekannten Gefahren bedroht und überwältigt von unglaublichen Eindrücken, entdeckt Carter wieder, was er verloren zu haben glaubte: seine Menschlichkeit. Schließlich erkennt er, dass die Zukunft des Planeten und das Überleben seiner Bewohner in seinen Händen liegen
| Taylor Kitsch | John Carter |
| Lynn Collins | Dejah Thoris |
| Samantha Morton | Sola |
| Mark Strong | Matai Shang |
| Dominic West | Sab Than |
| James Purefoy | Kantos Kan |
| Daryl Sabara | Edgar Rice Burroughs |
| Polly Walker | Sarkoja |
| Bryan Cranston | Powell |
| Willem Dafoe | Tars Tarkas |
| Thomas Haden Church | Tal Hajus |
| Rupert Frazer | Thompson |
| Nicholas Woodeson | Dalton |
| Amanda Clayton | Sarah Carter |
| Jeremy Booth | Doctor |
| Ciarán Hinds | Tardos Mors |
| Arkie Reece | Stayman #1 / Helm |
| Davood Ghadami | Stayman #3 |
| Pippa Nixon | Lightmaster |
| James Embree | Thern #2 |
| Philip Philmar | Thern #1 |
| Figs Jackman | Man in the Bowler |
| Emily Tierney | Pretty Woman in NYC Doorway |
| Edmund Kente | Telegraph Clerk |
| Kyle Agnew | Stable Boy |
| Don Stark | Dix the Storekeeper |
| Josh Daugherty | Rowdy #1 |
| Jared Cyr | Rowdy #2 |
| Sean Carrigan | Cavalryman |
| Dusty Sorg | Twitchy Corporal |
| Christopher Goodman | Stockade Guard |
| Akima | Apache Leader (as Akima Castaneda) |
| Joseph Billingiere | Apache #1 (as Joe Billingiere) |
| Aldred Montoya | Apache #2 (as Aldred Westley Montoya) |
| Phil Cheadle | Thern in Cave |
| David Schwimmer | Young Thark Warrior |
| Arnie Alpert | Council Member #1 |
| Ian Ray | Council Member #2 |
| Peggy Clements | Council Member #3 |
| Evelyn Dubuc | Council Member #4 |
| Jhil McEntyre | Council Member #5 (as Connie Jhil McEntyre) |
| Daniel O'Meara | Vas Kor |
| Emma Clifford | Lightman / Helm |
| Oliver Boot | Bodyguard (Matai) |
| Rebecca Sarker | Stayman #1 / Navigator |
| Philip Arditti | Spotter #2 |
| Jon Favreau | Thark Bookie |
| Art Malik | Zodangan General |
| Holly Weston | Carter's Wife (Corpse) |
| Gary Milner | Zodangan Guard |
| Cate Fowler | Matron of Chamber (Matai) |
| Darwin Shaw | Zodangan Officer (Matai) |
| Eileen Page | Elderly Woman (Matai) |
| Simon Evans | Zodangan Guard (as Si Evans) |
| Myriam Acharki | Priestess |
| Steven Cree | Humble Guard - Matai |
| Garry Tubbs | Orkney Dig Worker |
| Jill Baker | Additional Voice (voice) |
| Ekaterina Botziou | Dejah's Handmaiden (uncredited) |
| Shane B. Cook | Helium Soldier (uncredited) |
| Morgan Lester | Helium Guard (uncredited) |
| Thomas J. Post | Helium Soldier (uncredited) |
| Michael Giacchino | Composer |
| Daniel Mindel | Cinematographer |
| Eric Zumbrunnen | Editor |
| Marco Alicea | digital audio transfer |
| James Austin | engineering services |
| Chris Barron | dialogue assistant (as Christopher Barron) |
| Jaqui Baxter | Production Assistant |
| Jeremy Brown | boom operator: second unit additional crew |
| Jeanette Browning | adr recordist: Walt Disney Studios |
| Ben Burtt | sound consultant |
| Danny Caccavo | digital editing services |
| Brian Chumney | assistant supervising sound editor |
| John Countryman | video services |
| Coya Elliott | sound effects assistant |
| Noel Espinosa | Boom Operator |
| Malcolm Fife | Sound Effects Editor |
| Steve Finn | Boom Operator |
| Joseph L. Garrard | boom operator: second unit |
| Peter Gleaves | adr mixer: Goldcrest Studios |
| Josh Gold | foley editor |
| J.R. Grubbs | Sound Effects Editor |
| Nia Hansen | sound effects assistant |
| Alberto Hernandez | adr mixer: Fantasy Studios |
| Tom Johnson | re-recording mixer |
| Doc Kane | adr mixer: Walt Disney Studios |
| Noah Katz | digital editing services |
| Ren Klyce | sound consultant |
| Nick Kray | adr mixer: De Lane Lea Studios |
| Mike Lane | client services |
| Mary Jo Lang | foley mixer |
| Michael Levine | digital audio transfer |
| Dmitri Makarov | digital editing services |
| Paul H. Maritsas | sound mixer: second unit (as Paul Maritsas) |
| Jim McBride | sound engineer |
| Jeremy Molod | dialogue assistant |
| Alyson Dee Moore | foley artist (as Alyson Moore) |
| Steve Morris | engineering services |
| Chris Munro | Sound mixer |
