In a direct extension of his Nobel-prize-winning work on thermodynamics,Prigogine explains that almost all natural systems are non-determinsitic, even if all their components are subject to deterministic laws. This is because such systems have enormous numbers of Poincare resonances which lead to fundamentally non-deterministic solutions. This provides a solution to 3 of the most important problems in science: 1. Time's arrow 2. The Measurement Problem in QM 3. The existence of Freewill.
Everyone who is seriously interested in these questions should read this book.